Molecular Devices MultiClamp 700B Amplifier
General Specifications
- Applications: Single-channel recording, whole-cell patch-clamp recording, intracelluar sharp electrode recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study
- Smart telegraph: Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels
- Seal test: Yes
- Modes: I-Clamp, V-Clamp
- Holding potential range: -/+ 1000 mV
- Holding current range: -/+ 200 nA
- Output gain (mV/pA): 1.0 to 2000
- Open circuit noise in 5kHz and 10 kHz: 0.15 pA rms, (5 kHz), 0.28 pA rms (10 kHz)
- True voltage clamp-resistor feedback: True for for cSEVC
- Capacitance Compensation: Yes
- RMS Noise: 0.28 pA rms (10 kHz) at 50 GΩ to 3.0 pA rms (10 kHz) at 50 MΩ
- Automatic oscillation compression: Yes
- Automated mode-switching between current clamp and voltage clamp mode: Yes
- Slow current injection to maintain assigned potential: Yes
- True current clamp-voltage follower: Yes
- Simultaneous dual patch clamping recordings: Yes
- Computer control*: Yes
Dimensions
- Dimensions (in.): 3.5 (H)x 19 (W) x 12 (D)
- Dimensions (cm): 8.9 (H) x 48.3 (W) x 30.5 (D)
- Weight: 10 lbs. (4.54 kg)
- Headstage (in.): 0.875 (H) x 1.625(W) x 2.3125 (D)
- Headstage (cm): 2.0 (H) x 4.0 (W) x 8.4 (D)
- Channels: 2 (sharing a common ground)
- Communications: USB 1 Type B female ports
- Rack use: Standard 19" rack-mount (2U) with handles
- Benchtop use: Bayonet feet
- Power: 85-260 VAC, 50-60 Hz, 30 W (max)
- Safety: CE marking (Conformité Européenne)
Research Papers
-
Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation
Mehta, S. et al. (2018). Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation, Cell Reports, 25(4), pp. 1081-1096.e6. https://doi.org/10.1016/j.celr....
-
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation
Gelegen, C. et al. (2018). Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation, Current Biology, 28(4), pp. 580-587.e5.https://doi.org/10.1016/j.cub.....
-
Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude
Nicholson, E. et al. (2018). Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude, eLife, 7. https://doi.org/10.7554/elife.....
-
Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells
Van Den Hurk, M. et al. (2018). Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells, Frontiers in Molecular Neuroscience, 11. https://doi.org/10.3389/fnmol.....
-
A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina
Hellmer, C.B. et al. (2018). A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina, Physiological Reports, 6(20), p. e13885. https://doi.org/10.14814/phy2.....