Scientifica HyperScope
Performance measurements
These measurements were taken with two HyperScope systems, employing a Nikon 16X 0.8 NA 3 mm WD objective at 850 nm. The measured field of view at a scan angle of ±15° was 1 mm. The Point Spread Function measurements (below) were carried out by imaging 0.2µm polystyrene fluorescent beads mounted on the surface of a coverslip. From this figure you can see how our unique relay lens system enables having comparable resolution across the field of view.
The relay lenses also provide a constant intensity across the field of view, which can be observed on both the 3D surface plot and the 2D plot profile. Field flatness was mapped using a homogeneous fluorescent sample. Please note that the field of view of 1 mm corresponds only to the top portion of the plot.
Standard System
We can customise this system to suit your unique experimental needs. Please contact us to discuss your requirements.
SliceScope or VivoScope
Detector Unit MDU, MDU XL or FLIM detector
The scan mirrors on the imaging path can be configured as a galvo-galvo, resonant-galvo or galvo-galvo-resonant scan head.
A compact, flexible and efficient epifluorescence illuminator, optimised for use with LED light engines. Specifically designed for Scientifica microscopes, the FCM ensures optimal illumination of samples in all possible configurations.
Research Papers
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Non-canonical CB1 receptor signaling regulates night visual processing in the inner rat retina
Estay, S.F. et al. (2024) 'Non-canonical CB1 receptor signaling regulates night visual processing in the inner rat retina,' iScience, p. 109920. https://doi.org/10.1016/j.isci....
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Topographic axonal projection at single-cell precision supports local retinotopy in the mouse superior colliculus
Molotkov, D., Ferrarese, L., Boissonnet, T., & Asari, H. (2023). Topographic axonal projection at single-cell precision supports local retinotopy in the mouse superior colliculus. Nature Communications, 14(1). https://doi.org/10.1038/s41467...
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Principal neuron diversity in the murine lateral superior olive supports multiple sound localization strategies and segregation of information in higher processing centers
Haragopal, H. and Winters, B.D. Principal neuron diversity in the murine lateral superior olive supports multiple sound localization strategies and segregation of information in higher processing centers. Nature, 6(1). (2023) https://doi.org/10.1038/s42003....
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Paradoxical somato-dendritic decoupling supports cortical plasticity during REM sleep.
Mattia Aime, Niccolo’ Calcini, Micaela Borsa, Tiago Campelo, Thomas Rusterholz, Andrea Sattin, Tommaso Fellin & Antoine Adamantidis: Paradoxical somato-dendritic decoupling supports cortical plasticity during REM sleep. (2022) Science, In Press. https://www.science.org/doi/10.1126/science.abk2734
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CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain
Wang, L. et al. (2024) 'CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain,' Cell Reports, 43(4), p. 114120. https://doi.org/10.1016/j.celr....
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Regulation of synapse weakening through interactions of the microtubule associated protein tau with PACSIN1
Regan, P., Mitchell, S, J., Kim, S-C. et al. Regulation of synapse weakening through interactions of the microtubule associated protein tau with PACSIN1. Journal of Neuroscience (2021). https://doi.org/10.1523/JNEUROSCI.3129-20.2021
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An ON-type direction-selective ganglion cell in primate retina
Wang, A.Y. et al. (2023) 'An ON-type direction-selective ganglion cell in primate retina,' Nature, 623(7986), pp. 381–386. https://doi.org/10.1038/s41586....
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Mimicking hypomethylation of FUS requires liquid–liquid phase separation to induce synaptic dysfunctions
Kim, S.C. et al. (2023) 'Mimicking hypomethylation of FUS requires liquid–liquid phase separation to induce synaptic dysfunctions,' Acta Neuropathologica Communications, 11(1). https://doi.org/10.1186/s40478....
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Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity
Zheng, L., Yu, M., Lin, R. et al. Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity. Nat Commun 11, 3012 (2020). https://doi.org/10.1038/s41467-020-16826-0
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Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes
Lin RL, Frazier HN, Anderson KL, Case SL, Ghoweri AO, Thibault O. Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes. Aging Cell. (2022). https://pubmed.ncbi.nlm.nih.gov/35717599/
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Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia.
Zhang, S., Zhang, X., Zhong, H. et al. Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia. Nat Commun 13, 6890 (2022). https://doi.org/10.1038/s41467...
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Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons.
Requie, L.M., Gómez-Gonzalo, M., Speggiorin, M. et al. Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons. Nat Neurosci 25, 1639–1650 (2022). https://doi.org/10.1038/s41593...
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Activation of VIP interneurons in the prefrontal cortex ameliorates neuropathic pain aversiveness.
Miao Li, Hang Zhou, Sasa Teng, Guang Yang. Activation of VIP interneurons in the prefrontal cortex ameliorates neuropathic pain aversiveness. Cell Reports, Volume 40, Issue 11 (2022). https://doi.org/10.1016/j.celr...
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The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b
Jiang, X. et al. (2024) 'The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b,' PLoS Biology, 22(3), p. e3002565. https://doi.org/10.1371/journa....