Scientifica SliceScope Pro 1000
Technical Specifications

SliceScope Pro 1000 technical drawings

Standard System
We can customise this system to suit your unique experimental needs. Please contact us to discuss your requirements.
Slimline fully-motorised microscope
Perfect electrophysiology micromanipulator
50 mm of travel
Choose from the Scientifica PatchPad or Control Cube
Recording chamber & perfusion tools
Scientifica PatchStar Micromanipulator
- Number of axes: 3 with a virtual 4th axis
- Travel distance: 20mm per axis
- Electronic resolution: 20nm
- Minimum speed: 1µm per second
- Maximum speed: 4mm per second
- Memory positions: 50 on control device (unlimited via LinLab)
- Bearings: Crossed roller
- Software: LinLab for Windows
Scientifica XY Stage
- Number of axes: 2
- Travel distance: 50mm (in X and Y axes)
- Electronic resolution: 20nm
- Minimum step size: 0.1µm
- Minimum speed: 1µm per second
- Maximum speed: 4mm per second
- Memory position: 50 on control device (unlimited via LinLab)
- Software: LinLab for Windows
- Surface material: Anodised aluminium
Scientifica Post & Platform
- Minimum platform height: 105mm for a screw down base
- Maximum platform height: 350mm
- Mounting options: Screw down or magnetic base
Environmental Conditions
- Maximum altitude: 2000m
- Temperature range: 15°C to 40°C
- Maximum relative humidity: 60% for temperatures up to 31°C
Research Papers
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Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina
Bell, K.C. et al. (2025) 'Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina,' Neurobiology of Aging, 150, pp. 69–79. https://doi.org/10.1016/j.neur....
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High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.
Korgan, A.C., Oliveira-Abreu, K., Wei, W. et al. High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight. (2023). International Journal Obesity 47, 224 - 235. https://doi.org/10.1038/s41366...
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Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns.
Vasile, F., Dossi, E., Moulard, J., Ezan, P., Lecoin, L., Cohen-Salmon, M., Mailly, P., Le Bert, M., Couillin, I., Bemelmans, A. and Rouach, N. Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns. PLOS Biology, (2022) https://doi:10.1371/journal.pbio.3001891.
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Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala.
Walter Francesconi, Fulvia Berton, Valentina Olivera-Pasilio, Joanna Dabrowska. (2021). Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala. Neuropharmacology, 192. https://doi.org/10.1016/j.neuropharm.2021.108601
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GABAB receptors modulate Ca2+ but not G protein-gated inwardly rectifying K+ channels in cerebrospinal-fluid contacting neurones of mouse brainstem.
Jurčić, N., Er-Raoui, G., Airault, C., Trouslard, J., Wanaverbecq, N. and Seddik, R. (2019). GABAB receptors modulate Ca2+ but not G protein-gated inwardly rectifying K+ channels in cerebrospinal-fluid contacting neurones of mouse brainstem. J Physiol, 597: 631-651. https://doi.org/10.1113/JP277172
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Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex.
Hatch Robert J., Mendis G. Dulini C., Kaila Kai, Reid Christopher A., Petrou Steven. Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex. (2017). Frontiers in Cellular Neuroscience,11. https://doi.org/10.3389/fncel.2017.00204
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Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System.
Lisa Mapelli, Giuseppe Gagliano, Teresa Soda, Umberto Laforenza, Francesco Moccia, Egidio U. D'Angelo. Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. (2017) Journal of Neuroscience, 37 (5) 1340-1351. https://doi.org/10.1523/JNEURO...
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Cleaning patch-clamp pipettes for immediate reuse.
Kolb, I., Stoy, W., Rousseau, E. et al. Cleaning patch-clamp pipettes for immediate reuse. (2016). Sci Rep 6, 35001. https://doi.org/10.1038/srep35...
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Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors.
Ikuo Masuho and Olga Ostrovskaya and Grant M. Kramer and Christopher D. Jones and Keqiang Xie and Kirill A. Martemyanov. (2015). Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors. Science Signaling, 8. DOI: 10.1126/scisignal.aab406
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Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.
Laurie P. Sutton, Olga Ostrovskaya, Maria Dao, Keqiang Xie, Cesare Orlandi, Roy Smith, Sunmee Wee, Kirill A. Martemyanov. (2015). Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. Biological Psychiatry, 8, 235-245. https://doi.org/10.1016/j.biopsych.2015.07.026
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Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.
Ogg, M.C., Ross, J.M., Bendahmane, M. et al. Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation. Nat Commun 9, 1868 (2018). https://doi.org/10.1038/s41467...
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Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice.
Robert John Hatch, Gerhard Leinenga, Jürgen Götz. Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice. (2016). PLOS ONE. https://doi.org/10.1371/journal.pone.0164278
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Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight.
Tiago Branco, Adam Tozer, Christopher J. Magnus, Ken Sugino, Shinsuke Tanaka, Albert K. Lee, John N. Wood, Scott M. Sternson. (2016). Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight. Cell, 165, 1749-1761. https://doi.org/10.1016/j.cell...
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Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate.
Roberta de Ceglia, Linda Chaabane, Emilia Biffi, Andrea Bergamaschi, Giancarlo Ferrigno, Stefano Amadio, Ubaldo Del Carro, Nausicaa Mazzocchi, Giancarlo Comi, Veronica Bianchi, Stefano Taverna, Lia Forti, Patrizia D’Adamo, Gianvito Martino, Andrea Menegon, Luca Muzio. Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate. (2015). Brain, Behavior, and Immunity, 45, 263-276. https://doi.org/10.1016/j.bbi.....
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Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model.
Marcantoni, A., Raymond, E.F., Carbone, E. et al. Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model. (2014) Pflugers Arch - Eur J Physiol, 466, 1437–1450. https://doi.org/10.1007/s00424...
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Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAA Receptors during Spillover.
Damian P. Bright, Massimiliano Renzi, Julian Bartram, Thomas P. McGee, Georgina MacKenzie, Alastair M. Hosie, Mark Farrant and Stephen G. Brickley. (2011). Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAA Receptors during Spillover. Journal of Neuroscience, 31 (2) 753-763. https://doi.org/10.1523/JNEURO...
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Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B.
Yan Jiang, Mira Jakovcevski, Rahul Bharadwaj, Caroline Connor, Frederick A. Schroeder, Cong L. Lin, Juerg Straubhaar, Gilles Martin and Schahram Akbarian. Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B. (2010). Journal of Neuroscience, 30 (21) 7152-7167. https://doi.org/10.1523/JNEURO...